The Banerjee laboratory is studying how hormones regulate metabolism, with a particular focus on glucose homeostasis. We use the pancreatic beta-cell as our model system. These amazing cells sense and integrate inputs from numerous hormones and metabolites to regulate secretion of hormones, including insulin, that in turn regulate metabolism in many tissues. Beta-cell failure to produce sufficient insulin underlies the development of diabetes mellitus.
Our work has demonstrated a critical role for prolactin receptor (PRLR) and lactogen signaling in the beta-cell adaptations required to maintain euglycemia during pregnancy. Defective PRLR signaling in mice results in gestational diabetes mellitus (GDM).
We are currently investigating targets of PRLR signaling responsible for maternal adaptation of beta-cells during pregnancy, and how these pathways may be deranged in GDM. Additionally, we are interested in molecular mechanisms underlying gestational beta-cell expansion and regression to pre-pregnancy levels following parturition. We are also exploring roles for PRLR regulation of maternal adaptation in other tissues during gestation.
To address these questions, we apply cutting-edge techniques in molecular and cellular biology, genetics and developmental biology. Our ultimate aim is to use information from these studies to identify pathways and targets that can be exploited to develop new therapies for diabetes in humans.